MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman.  MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. 
What is the MCF-7 cell line? MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26 ]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [ 27 ].
What is MCF-7 human adenocarcinoma cells? 4.8.1MCF-7 human adenocarcinoma cells MCF-7is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors . It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI .
Why are MCF-7 cells useful for in vitro breast studies? MCF-7 cells are useful for in vitro breast studies because they retained several ideal characteristics particular to mammary epithelium, such as the processing of estrogen, in the form of estradiol, via estrogen receptors (ER) in the cell cytoplasm [ 28 ]. It is the first hormone responding breast cancer cell line.
Why are MCF-7 and MDA-MB-231 selected? For example, the MCF-7 cells were chosen because they are ERα+, non-invasive, human breast cancer cells, and a commonly used cell line for human breast cancer studies. The MDA-MB-231 cells, obtained from a patient in 1973 at MD Anderson Center, were chosen as an ER negative cell line with invasive phenotype, in vitro.
What are MCF7 cells? MCF7 are epithelial cells isolated from the breast tissue of a 69-year-old, White, female patient with metastatic adenocarcinoma. Use these cells in your breast cancer research. Discounts may be available for our fellow nonprofit organizations. Login to see your price.
What is the growth and morphology of MCF7 (ATCC htb-22) cells? What is the growth and morphology of MCF7 (ATCC HTB-22) cells? MCF7 (ATCC HTB-22) is typically a slow-growing cell line and will appear as loosely attached three-dimensional clusters with some floating viable cells.
Does estrogen modulate MCF7 human breast cancer cell proliferation? Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media. Cancer Res. 53: 5193-5198, 1993.
How should I store my MCF-7 (ATCC htb-22)? Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen. Derived from MCF-7 ( ATCC HTB-22) cell line, continuously cultured with 1 µM 4-OH-tamoxifen for 8-12 months to obtain a tamoxifen resistant cell line Check all containers for leakage or breakage.
What is the MCF-7 cell line?
What do you know about MCF-7? MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25000 scientific publications that used this cell line, how many know the unique story of its isolation and development?
What is MCF-7 breast cancer cell line? The Story of MCF-7 Breast Cancer Cell Line: 40 years of Experience in Research Breast cancer is the most frequent malignancy in females. Due to its major impact on population, this disease represents a critical public health problem that requires further research at the molecular level in order to define its prognosis and specific treatment.
Is MCF-7 a PRLR variant? MCF-7 is an adherent, epithelial luminal cell line positive for estrogen and progesterone receptors. Although they are referred to as hormone-dependent, the minimal amount of steroid hormones present in serum is sufficient to ensure cell growth. This cell line was used to evaluate the functional impact of PRLR variants in a mammary cell context.
What is mcf10 breast cancer? The MCF10 series of cell lines capture the entire spectrum of premalignant to malignant breast cancer. Breast cancer is a heterogeneous disease, and the heterogeneous spectrum of disease progression exhibited by the MCF10 cell series reflects its multi-potentiality.