The SNc T1w/T2w ratio had high sensitivity (0.908) and specificity (0.80) to separate PD and controls (area under the curve [AUC] = 0.926), even for PDE patients (AUC = 0.901, sensitivity = 0.857, specificity = 0.857). These results were validated in the second cohort.
Does SNC t1w/t2w ratio separate PD and controls? The SNc T1w/T2w ratio had high sensitivity (0.908) and specificity (0.80) to separate PD and controls (area under the curve [AUC] = 0.926), even for PDE patients (AUC = 0.901, sensitivity = 0.857, specificity = 0.857). These results were validated in the second cohort.
Is the t1w/t2w ratio a marker of General myelin microstructure? Although the sensitivity of the T1w/T2w ratio to myelin has been contested, there is growing consensus that the T1w/T2w ratio is a marker of general WM microstructure ( 15 – 17 ). Recently, reduced T1w/T2w ratio intensity values have been found in the cortex and NAWM of MS patients compared to HC ( 15, 17 ).
Is t1w/t2w ratio a new in vivo biomarker for Parkinson’s disease? Interpretation: The T1w/T2w ratio can detect PD-related changes in the SNc and may be used as a novel, parsimonious in vivo biomarker for the disease, particularly for early stage patients, with high translational value for clinical practice and research. ANN NEUROL 2019;85:96-104.
Does t1w/t2w ratio affect normal appearing white matter in multiple sclerosis? Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS) and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a measure of white matter integrity, has previously shown reduced intensity values in MS NAWM.
Does SNC t1w/t2w ratio separate PD and controls?
Does SNC t1w/t2w ratio separate PD and controls in PDE patients? The SNc T1w/T2w ratio had high sensitivity (0.908) and specificity (0.80) to separate PD and controls (area under the curve [AUC] = 0.926), even for PDE patients (AUC = 0.901, sensitivity = 0.857, specificity = 0.857). These results were validated in the second cohort.
Is t1w/t2w ratio a new biomarker for Parkinson’s disease? The T1w/T2w ratio can detect PD-related changes in the SNc and may be used as a novel, parsimonious in vivo biomarker for the disease, particularly for early stage patients, with high translational value for clinical practice and research. ANN NEUROL 2019;85:96–104.
Is the st1w/t2w ratio an effective measure of NAWM in MS? The sT1w/T2w ratio shows promise as an easily-implemented measure of NAWM in MS using readily available scans and simple post-processing methods.
Does t1w/t2w ratio affect normal appearing white matter in multiple sclerosis? Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS) and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a measure of white matter integrity, has previously shown reduced intensity values in MS NAWM.